(2-Fluoro-3-methoxy-4-nitrophenyl)methanol → 1-(Chloromethyl)-2-fluoro-3-methoxy-4-nitrobenzene

HRID 511358Notes

Reaction equation

HRID 511358 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([N+:11]([O-:13])=[O:12])=[CH:5][C:4]=1F.[F:15]C1C(OC)=C([N+]([O-])=O)C=CC=1CO>>[Cl:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([N+:11]([O-:13])=[O:12])=[C:7]([O:9][CH3:10])[C:8]=1[F:15]

Participants

3

Reactant 2

HCID 67254223(2-Fluoro-3-methoxy-4-nitrophenyl)methanol2×HCID 672551071-(Chloromethyl)-2-fluoro-5-methoxy-4-nitrobenzene

Product 1

HCID 672549481-(Chloromethyl)-2-fluoro-3-methoxy-4-nitrobenzene

Procedure

The title compound was prepared using the procedure from Compound 130C (1-(chloromethyl)-2-fluoro-5-methoxy-4-nitrobenzene) with (2-fluoro-3-methoxy-4-nitrophenyl)methanol (Compound 147D). 1H NMR (CDCl3, 400 MHz): δ=4.10 (d, J=1.77 Hz, 3 H), 4.64 (d, J=1.52 Hz, 2 H), 7.62 (dd, J=8.59, 1.77 Hz, 1 H). MS (ES+): m/z 220.00 [MH+] (TOF, polar).

Sources & evidence

ORD record
ord-835ddf2f62bc4739a4f4549b5baf9233
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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