2-Fluoro-3-methoxy-4-nitrobenzoic acid → (2-Fluoro-3-methoxy-4-nitrophenyl)methanol

HRID 511359Notes

Reaction equation

HRID 511359 reaction equation
FC1C=C([N+]([O-])=O)C(OC)=CC=1CO.[F:15][C:16]1[C:24]([O:25][CH3:26])=[C:23]([N+:27]([O-:29])=[O:28])[CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19]>>[F:15][C:16]1[C:24]([O:25][CH3:26])=[C:23]([N+:27]([O-:29])=[O:28])[CH:22]=[CH:21][C:17]=1[CH2:18][OH:19]

Participants

3

Reactant 2

HCID 579556232-Fluoro-3-methoxy-4-nitrobenzoic acid2×HCID 67255286(2-Fluoro-5-methoxy-4-nitrophenyl)methanol

Product 1

HCID 67254223(2-Fluoro-3-methoxy-4-nitrophenyl)methanol

Procedure

The title compound was prepared using the procedure from Compound 130D ((2-fluoro-5-methoxy-4-nitrophenyl)methanol) with 2-fluoro-3-methoxy-4-nitrobenzoic acid (Compound 147E). 1H NMR (CDCl3, 400 MHz): δ=4.08 (d, J=1.77 Hz, 3 H), 4.85 (s, 2 H), 7.29-7.35 (m, 1 H), 7.64 (dd, J=8.46, 1.89 Hz, 1 H).

Sources & evidence

ORD record
ord-edea00627a624e24a8a9bc4b74a5b216
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

Loading…