Methylamine → HCID 67254135, compound

HRID 511381Notes

Reaction equation

HRID 511381 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[C:5]=1[C:6](OC)=[O:7])(=[O:3])[CH3:2].[CH3:17][NH2:18]>C(O)C>[OH:3][C:1]1([CH3:2])[C:4]2[C:5](=[C:10]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:12][CH:13]=2)[C:6](=[O:7])[N:18]1[CH3:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 59644399Methyl 2-acetyl-6-nitrobenzoate

Product 1

HCID 67254135HCID 67254135, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 2-acetyl-6-nitrobenzoate (2 g, 8.96 mmol) and 33% methylamine in ethanol (10 mL) was stirred at reflux for 14 h. The solvents were removed under reduced pressure to afford 1.7 g of the desired product (yield: 85%). 1H NMR (CDCl3, 300 MHz): δ=1.80 (s, 3 H), 3.05 (s, 3 H), 7.78 (m, 2 H), 7.95 (m, 1 H).

Workup

  1. temperatureat reflux for 14 h
  2. customThe solvents were removed under reduced pressure

Sources & evidence

ORD record
ord-cd4d4108813142578c8fc733a6d2c6df
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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