7-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one → 7-Amino-2-methyl-4-(morpholin-4-yl)-2,3-dihydro-1H-isoindol-1-one

HRID 511448Notes

Reaction equation

HRID 511448 reaction equation
NC1C=CC(OC)=C2C=1C(=O)N(C)C2.[CH3:15][N:16]1[CH2:24][C:23]2[C:18](=[C:19]([N+:31]([O-])=O)[CH:20]=[CH:21][C:22]=2[N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:17]1=[O:34]>>[NH2:31][C:19]1[CH:20]=[CH:21][C:22]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[C:23]2[C:18]=1[C:17](=[O:34])[N:16]([CH3:15])[CH2:24]2

Participants

3

Reactant 2

HCID 672539417-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one2×HCID 672540622-Methyl-4-(morpholin-4-yl)-7-nitro-2,3-dihydro-1H-isoindol-1-one2×

Product 1

HCID 672538067-Amino-2-methyl-4-(morpholin-4-yl)-2,3-dihydro-1H-isoindol-1-one

Procedure

The title compound was prepared according to the procedure for 7-Amino-4-methoxy-2-methyl-2,3-dihydro-1H-isoindol-1-one (Compound 205A) using 2-Methyl-4-(morpholin-4-yl)-7-nitro-2,3-dihydro-1H-isoindol-1-one (Compound 208B). MS (ES+): m/z 248.23 (100) [MH+]; HPLC: tR=0.62 min (UPLC, analytical).

Sources & evidence

ORD record
ord-c6f0a66c30704228b4f35cb70321d64e
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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