Cesium carbonate → HCID 58293049, compound

HRID 511453Notes

Reaction equation

HRID 511453 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([NH:13][C:14]2[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][N:17]=[C:16]([NH:24][C:25]3[CH:39]=[CH:38][C:28]([CH2:29][P:30](=[O:37])([O:34][CH2:35][CH3:36])[O:31][CH2:32][CH3:33])=[CH:27][CH:26]=3)[N:15]=2)=[C:6]2[C:10]=1[CH2:9][N:8]([CH3:11])[C:7]2=[O:12].[NH:40]1[CH2:45][CH2:44][S:43](=[O:47])(=[O:46])[CH2:42][CH2:41]1.C([O-])([O-])=O.[Cs+].[Cs+].[O-]P([O-])([O-])=O.[K+].[K+].[K+]>>[O:46]=[S:43]1(=[O:47])[CH2:44][CH2:45][N:40]([C:2]2[CH:3]=[CH:4][C:5]([NH:13][C:14]3[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][N:17]=[C:16]([NH:24][C:25]4[CH:39]=[CH:38][C:28]([CH2:29][P:30](=[O:37])([O:34][CH2:35][CH3:36])[O:31][CH2:32][CH3:33])=[CH:27][CH:26]=4)[N:15]=3)=[C:6]3[C:10]=2[CH2:9][N:8]([CH3:11])[C:7]3=[O:12])[CH2:41][CH2:42]1

Participants

5

Reactant 4

HCID 10796Cesium carbonateHCID 62657Potassium Phosphate, TribasicHCID 6484228Thiomorpholine 1,1-dioxideHCID 58292897Diethyl [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate

Product 1

HCID 58293049HCID 58293049, compound

Procedure

The title compound was prepared according to the procedure for Example 199 using Diethyl [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate and thiomorpholine-1,1-dioxide and replacing Cs2CO3, with K3PO4. MS (ES+): m/z 683.25 (100) [MH+]; HPLC: tR=0.98 min (UPLC, purity).

Sources & evidence

ORD record
ord-5dc13b4f6ca8411d8a10d2a8321b4db6
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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