2,4-Dichloro-5-(trifluoromethyl)pyrimidine → 2-chloro-N-{4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}-5-(trifluoromethyl)pyrimidin-4-amine

HRID 511469Notes

Reaction equation

HRID 511469 reaction equation
[Cl:1][C:2]1C(C(F)(F)F)=CN=[C:4]([NH:12][C:13]2[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20]C)=[CH:15][CH:14]=2)[N:3]=1.O=P1(CC2C=CC(N)=CC=2)OCCCO1.ClC1N=C(Cl)[C:47]([C:51]([F:54])([F:53])[F:52])=[CH:46][N:45]=1>>[Cl:1][C:2]1[N:3]=[C:4]([NH:12][C:13]2[CH:14]=[CH:15][C:16]([CH2:17][P:18]3(=[O:25])[O:19][CH2:20][CH2:24][CH2:23][O:22]3)=[CH:26][CH:27]=2)[C:47]([C:51]([F:54])([F:53])[F:52])=[CH:46][N:45]=1

Participants

4

Reactant 3

HCID 27827742,4-Dichloro-5-(trifluoromethyl)pyrimidineHCID 112991132-(4-Aminobenzyl)-1,3,2-dioxaphosphorinane-2-oxide2×HCID 86654003Diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Product 1

HCID 582929812-chloro-N-{4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}-5-(trifluoromethyl)pyrimidin-4-amine

Procedure

The title compound was prepared according to the procedure for diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate using 4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]aniline (Compound 230C) and 2,4-dichloro-5-trifluoromethylpyrimidine.

Sources & evidence

ORD record
ord-c212287c6e804cf0b772b6ab566c3f2c
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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