2,4-Dichloro-5-(trifluoromethyl)pyrimidine → 2-chloro-N-{4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}-5-(trifluoromethyl)pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	2,4-Dichloro-5-(trifluoromethyl)pyrimidine	HCID 2782774	—
Reactant	2-(4-Aminobenzyl)-1,3,2-dioxaphosphorinane-2-oxide	HCID 11299113	—
Reactant	Diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate	HCID 86654003	—
Product	2-chloro-N-{4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}-5-(trifluoromethyl)pyrimidin-4-amine	HCID 58292981	—

Reaction Steps

The title compound was prepared according to the procedure for diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate using 4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]aniline (Compound 230C) and 2,4-dichloro-5-trifluoromethylpyrimidine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096624B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-c212287c6e804cf0b772b6ab566c3f2c
Source note	uspto-grants-2015_08