反应详情

60 g (242 mmol) of 4-(4,4,4-trifluorobutoxy)benzoic acid, 31.8 ml (314 mmol) of propane-1,3-dithiol and 27.9 ml (314 mmol) of trifluoromethanesulfonic acid are refluxed in 1.61 of a mixture 1/1 isooctane/toluene for 18 hours. The mixture is cooled down and the product is precipitated by addition of 1.5 l of TBME to yield 108 g of 2-[4-(4,4,4-trifluorobutoxy)phenyl]-5,6-dihydro-4H-1,3-dithiin-1-ium trifluoromethanesulfonate as yellow crystals.

1. temperatureThe mixture is cooled down
2. customthe product is precipitated by addition of 1.5 l of TBME