反应详情

3-Bocamino-1,2-propanediol (144.7 g; 0.757 mol) was suspended in water (750 ml) and potassium periodate (191.5 g; 0.833 mol) was added. The mixture was stirred under nitrogen for 2.5 h and the precipitated potassium iodate was removed by filtration and washed once with water (100 ml). The aqueous phase was extracted with chloroform (6×400 ml). The chloroform extracts were dried and evaporated to dryness, in vacuo. Yield 102 g (93%) of an oil. The (bocamino)acetaldehyde was purified by kugelrohr distillation at 84° C. and 0.3 mmHg in two portions. The yield 79 g (77%) of a colorless oil.

1. customthe precipitated potassium iodate was removed by filtration
2. washwashed once with water (100 ml)
3. extractionThe aqueous phase was extracted with chloroform (6×400 ml)
4. dry with materialThe chloroform extracts were dried
5. customevaporated to dryness, in vacuo
6. distillationThe (bocamino)acetaldehyde was purified by kugelrohr distillation at 84° C.