反应详情

To an acetonitrile (5 ml) solution of methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate (300 mg, 1.2 mmol) were added potassium carbonate (1.0 g, 7.4 mmol) and iodomethane (350 mg, 2.5 mmol) at room temperature respectively. The mixture was stirred at room temperature for 4 hours. The solid was removed by filtration and washed with acetonitrile. The filtrate was concentrated in vacuo. After being filtered off, the filtrate was concentrated under reduced pressure, the residue was applied to a silica gel chromatography column and eluted with a hexane/ethyl acetate=4/1 to furnish 239 mg (75% yield, major product) of the title as a white solid;

1. customThe solid was removed by filtration
2. washwashed with acetonitrile
3. concentrationThe filtrate was concentrated in vacuo
4. filtrationAfter being filtered off
5. concentrationthe filtrate was concentrated under reduced pressure
6. washeluted with a hexane/ethyl acetate=4/1
7. customto furnish 239 mg (75% yield, major product) of the title as a white solid