Hydrochloric Acid → HCID 67291970, compound

HRID 511839Notes

Reaction equation

HRID 511839 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=2)[CH:4]=[C:3]1[C:15]([O:17]CC)=[O:16].[OH-].[Na+].Cl>CO>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([F:13])([F:14])[F:12])[CH:9]=2)[CH:4]=[C:3]1[C:15]([OH:17])=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67291579HCID 67291579, compound

Product 1

HCID 67291970HCID 67291970, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of ethyl 1-methyl-6-(trifluoromethyl)-1H-indole-2-carboxylate (90 mg, 0.33 mmol) and 2 mol/L aqueous sodium hydroxide solution (0.42 mL, 0.83 mmol) in methanol (2 mL) was stirred at room temperature for 2 hours. Then, 2 mol/L hydrochloric acid was added, and the formed precipitate was collected by filtration to give 75.6 mg (94% yield) of the title compound as a white solid:

Workup

  1. filtrationthe formed precipitate was collected by filtration

Sources & evidence

ORD record
ord-b9dea32817e84dd4815538e7fb7f8019
Source dataset
uspto-grants-2015_08
Patent number
US09101616B2

Reaction notes

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