反应详情

To a mixture of 3,4-diaminobenzonitrile (326 mg, 2.45 mmol), trans-2-(ethoxycarbonyl)cyclopropanecarboxylic acid (323 mg, 2.04 mmol), and triethylamine (1.44 mL, 10.2 mmol) in DMF (10 mL) was added HBTU (1.01 g, 2.66 mmol). After stirring at room temperature for 3 h, the mixture was poured into water, and the aqueous phase was extracted with EtOAc twice. The combined organic layer was dried over sodium sulfate and concentrated in vacuo. To the residue was added acetic acid (10 mL), and the mixture was stirred at 90° C. for 12 h. After cooling to room temperature, the solvent was removed in vacuo. The residue was poured into saturated sodium bicarbonate aqueous solution, and the aqueous layer was extracted with EtOAc twice. The combined organic layers were dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate to give 210 mg (40%) of the title compound as a white amorphous:

1. extractionthe aqueous phase was extracted with EtOAc twice
2. dry with materialThe combined organic layer was dried over sodium sulfate
3. concentrationconcentrated in vacuo
4. additionTo the residue was added acetic acid (10 mL)
5. stirringthe mixture was stirred at 90° C. for 12 h
6. temperatureAfter cooling to room temperature
7. customthe solvent was removed in vacuo
8. additionThe residue was poured into saturated sodium bicarbonate aqueous solution
9. extractionthe aqueous layer was extracted with EtOAc twice
10. dry with materialThe combined organic layers were dried over sodium sulfate
11. concentrationconcentrated in vacuo
12. customThe residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate