Methyl 3-(2-methyl-6-nitrophenyl)propenoate → methyl 4-methyl-1H-indole-2-carboxylate

Participants

Reaction Steps

Methyl 3-(2-methyl-6-nitrophenyl)propenoate (0.24 g, 1.1 mmol) was dissolved in triethylphosphite (1 mL) and heated under reflux for 20 h. The solvent was removed in vacuo and the crude product was purified by silica gel chromatography (EtOAc:hexane=8:92) to give 0.15 g (71% yield) of the title compound as a pale yellow solid:

Provenance & Evidence