反应详情

2-methoxy-5-nitroaniline (1) (10.1 g, 600 mmol) in 250 mL dichloromethane at 0°-5° C. was treated with triethylamine (10.0 g, 100.0 mmol) and propionyl chloride (6.7 g, 6.3 mL, 720 mmol) for 1 hour and 0.5 h at room temperature (RT). Normal aqueous workup and removal of solvent gave a light yellow solid which was washed with hexane/EtOAc (9:1) to yield solid N-(2-Methoxy-5-nitro-phenyl)-propionamide (2) (13.2 g, 98%).

1. customNormal aqueous workup and removal of solvent
2. customgave a light yellow solid which
3. washwas washed with hexane/EtOAc (9:1)