反应详情

10 g (72.4 mmol) of salicylic acid and 6.1 ml (76 mmol) of pyridine are placed in 100 ml of acetone at −5° C. 9.3 ml (76 mmol) of 2,2-dimethylpropionyl chloride are added and, after stirring at ambient temperature for 2 hours, water is added and the mixture is extracted with dichloromethane. The organic phase is dried over magnesium sulphate, filtered and concentrated. The residue is precipitated from heptane at 0° C. and then filtered off. 16.9 g of 2-(2,2-dimethylpropionyloxy)benzoic acid are obtained in the form of a white powder with a yield of 95%.

1. extractionthe mixture is extracted with dichloromethane
2. dry with materialThe organic phase is dried over magnesium sulphate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue is precipitated from heptane at 0° C.
6. filtrationfiltered off