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HRID511944

反应详情

EQUATION

反应方程式

HRID 511944 的结构方程式

REACTANTS

反应物

3
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：[Na]
HCID5360545

Sodium

Na

结构：CCN(C(=O)c1c(O)c2c(Cl)cccc2n(C)c1=O)c1ccccc1
HCID54677946

Laquinimod

C19H17ClN2O3

PRODUCTS

生成物

1
结构：CCN(C(=O)c1c([O-])c2c(Cl)cccc2n(C)c1=O)c1ccccc1.[Na+]
HCID23697158

Laquinimod sodium

C19H16ClN2NaO3

收率 92%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Deuterated laquinimod prepared in Step 2 was suspended in ethanol and treated with 20% aqueous NaOH solution. The precipitated sodium salt was stirred for 3 hours, filtered and washed with ethanol. Drying in vacuum provided deuterated laquinimod sodium salt (92-94% yield). Identity and purity were proven by NMR, MS and HPLC.

WORKUP

后处理

  1. filtrationfiltered
  2. washwashed with ethanol
  3. customDrying in vacuum