HCID 66930896, compound → HCID 66930907, compound

HRID 511958Notes

Reaction equation

HRID 511958 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:5][CH:4]=1>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 66930896HCID 66930896, compound

Product 1

HCID 66930907HCID 66930907, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of 7.1 (1.19 g, 4.03 mmol) in AcOEt (40 mL) at room temperature was added 10% Pd/C (0.18 g, 15% w/w) and the resulting suspension was hydrogenated (30 psi, 6 h). The catalyst was removed by filtration through celite and the filtrate was evaporated under reduced pressure to give the title compound (8.1) (1.14 g, 95% yield) as a white solid (m p 32-34° C.).

Workup

  1. custom(30 psi, 6 h)
  2. customThe catalyst was removed by filtration through celite
  3. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-4bc8de92789f45f297b9d3f627d56ebf
Source dataset
uspto-grants-2015_08
Patent number
US09102622B2

Reaction notes

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