Boron trifluoride etherate → HCID 23725185, compound

HRID 511980Notes

Reaction equation

HRID 511980 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][S:22]([F:25])(=[O:24])=[O:23])C1C=CC=CC=1.B(F)(F)F.CCOCC>C(S)(S)C>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][S:22]([F:25])(=[O:24])=[O:23]

Participants

4

Reactant 2

HCID 8000Boron trifluoride etherateHCID 25017346HCID 25017346, compound

Product 1

HCID 23725185HCID 23725185, compoundYield 70.8%

Reagents, catalysts & solvents 1

HCID 336451,1-EthanedithiolSolvent

Procedure

7-(2-Hydroxy-phenyl)-heptanesulfonyl fluoride (14.3) was synthesized as described in 14.1 using 13.3 (0.065 g, 0.17 mmol) in ethanedithiol (5 mL) and BF3.Et2O (0.092 g, 0.65 mmol). Purification by flash column chromatography gave 14.3 (0.033 g, 70% yield) as a viscous liquid.

Workup

  1. custom7-(2-Hydroxy-phenyl)-heptanesulfonyl fluoride (14.3) was synthesized
  2. customPurification by flash column chromatography

Sources & evidence

ORD record
ord-bf41d6e3025a42889c28941f381fa978
Source dataset
uspto-grants-2015_08
Patent number
US09102622B2

Reaction notes

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