反应详情

温度

0 °C

To a solution of 3-phenylpropyl isocyanate (1.8 mmol) in anhydrous THF (10 mL) at 0° C. under an argon atmosphere was added 2-aminomethyl-pyridine (1.8 mmol). The reaction mixture was stirred at 0° C. for 10 min, the solvent was evaporated under reduced pressure, and the resultant solid was recrystallized from CH2Cl2/Et2O to give pure 59.1 in 92% yield. White solid. m p 89-90° C. When anhydrous benzene was used as solvent the product was directly crystallized out and isolated by filtration (93% yield).

1. customthe solvent was evaporated under reduced pressure
2. customthe resultant solid was recrystallized from CH2Cl2/Et2O
3. customto give pure 59.1 in 92% yield
4. customm p 89-90° C
5. customwas directly crystallized out
6. customisolated by filtration (93% yield)