Methanol → HCID 22955958, compound

HRID 512031Notes

Reaction equation

HRID 512031 reaction equation
[CH3:1][OH:2].[F:3][C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6](Cl)=[O:7]>C(OCC)(=O)C>[F:3][C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6]([O:2][CH3:1])=[O:7]

Participants

4

Reactant 2

HCID 887MethanolHCID 136574572,5-Difluoro-4-Methylbenzoyl chloride

Product 1

HCID 22955958HCID 22955958, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Methanol (10 mL) was added to 2,5-difluoro-4-methyl-benzoyl chloride (500 mg, 2.6 mmol) and the solution evaporated to give an oil. The oil was dissolved in ethyl acetate and extracted with saturated aqueous sodium carbonate solution (20 mL) and brine (2×20 mL). The organic layer was separated, dried over sodium sulphate, filtered and concentrated in vacuo to afford the title compound as clear colourless solid (300 mg, 62%).

Workup

  1. customthe solution evaporated
  2. customto give an oil
  3. extractionextracted with saturated aqueous sodium carbonate solution (20 mL) and brine (2×20 mL)
  4. customThe organic layer was separated
  5. dry with materialdried over sodium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ecd616f47f32469bbabbb68d75938e15
Source dataset
uspto-grants-2015_08
Patent number
US09102621B2

Reaction notes

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