HRID51211

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：O=C(O)/C=C\C(=O)O$

HCID444266

Maleic acid

C4H4O4

结构：CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O

HCID5388962

Enalapril

C20H28N2O5

PRODUCTS

生成物

$结构：CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O.O=C(O)/C=C\C(=O)O$

HCID5388961

Enalapril maleate

C24H32N2O9

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

CONDITIONS

反应条件

温度: 70 °C

PROCEDURE

实验过程

N-(1(S)-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline and acetonitrile are mixed and to this mixture is added maleic acid with heating at 70° C. and the mixture is gradually cooled to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline maleate.

WORKUP

后处理

temperaturethe mixture is gradually cooled