2-Chloro-5-methylbenzoic Acid → 2-Chloro-5-methyl-N-(1-methyl-4-phenyl-piperidin-4-ylmethyl)-benzamide

HRID 512218Notes

Reaction equation

HRID 512218 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][N:13]1[CH2:18][CH2:17][C:16]([CH2:25][NH2:26])([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:15][CH2:14]1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([NH:26][CH2:25][C:16]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]1)=[O:6]

Participants

3

Reactant 2

HCID 2404302-Chloro-5-methylbenzoic AcidHCID 343885(1-Methyl-4-phenylpiperidin-4-yl)methanamine

Product 1

HCID 867162512-Chloro-5-methyl-N-(1-methyl-4-phenyl-piperidin-4-ylmethyl)-benzamide

Procedure

From 2-chloro-5-methylbenzoic acid and C-(1-methyl-4-phenyl-piperidin-4-yl)-methylamine. LCMS (MH+): m/z=367.0, tR (minutes, Method A)=0.68

Sources & evidence

ORD record
ord-40dd52f5c4c4449a9262230e19477e29
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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