2-Chloro-5-methylbenzoic Acid → 2-Chloro-5-methyl-N-[4-(6-methyl-pyridin-3-yl)-tetrahydro-pyran-4-ylmethyl]-benzamide

HRID 512224Notes

Reaction equation

HRID 512224 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[N:18]=[CH:17][C:16]([C:19]2([CH2:25][NH2:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:15][CH:14]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([NH:26][CH2:25][C:19]1([C:16]2[CH:17]=[N:18][C:13]([CH3:12])=[CH:14][CH:15]=2)[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1)=[O:6]

Participants

3

Reactant 2

HCID 2404302-Chloro-5-methylbenzoic AcidHCID 86716258C-[4-(6-methylpyridin-3-yl)-tetrahydropyran-4-yl]methylamine

Product 1

HCID 867162572-Chloro-5-methyl-N-[4-(6-methyl-pyridin-3-yl)-tetrahydro-pyran-4-ylmethyl]-benzamide

Procedure

From 2-chloro-5-methylbenzoic acid and C-[4-(6-methylpyridin-3-yl)-tetrahydropyran-4-yl]methylamine. LCMS (MH+): m/z=359.0, tR (minutes, Method B)=0.74

Sources & evidence

ORD record
ord-915f77ae638b47e38a0940c7e9234d0e
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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