2-Methyl-5-(trifluoromethyl)benzoic acid → N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-2-methyl-5-trifluoromethyl-benzamide

HRID 512250Notes

Reaction equation

HRID 512250 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[CH:5][C:6]([CH3:12])=[C:7]([CH:11]=1)[C:8]([OH:10])=O.[F:15][C:16]1([F:34])[CH2:21][CH2:20][C:19]([CH2:32][NH2:33])([C:22]2[CH:23]=[N:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=2)[CH2:18][CH2:17]1>>[F:34][C:16]1([F:15])[CH2:17][CH2:18][C:19]([CH2:32][NH:33][C:8](=[O:10])[C:7]2[CH:11]=[C:3]([C:2]([F:1])([F:14])[F:13])[CH:4]=[CH:5][C:6]=2[CH3:12])([C:22]2[CH:23]=[N:24][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:26][CH:27]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 27755852-Methyl-5-(trifluoromethyl)benzoic acidHCID 86716274(4,4-Difluoro-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexyl)methanamine

Product 1

HCID 86716289N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-2-methyl-5-trifluoromethyl-benzamide

Procedure

From 5-trifluoromethyl-2-methylbenzoic acid and C-[4,4-difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=481.1, tR (minutes, Method D)=0.86

Sources & evidence

ORD record
ord-2bbf6625f0e44c28a1ab78eca2a3a6ca
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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