Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512250Generated: October 26, 2026

2-Methyl-5-(trifluoromethyl)benzoic acid → N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-2-methyl-5-trifluoromethyl-benzamide

https://huagongshe.com/reaction/512250

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-5-(trifluoromethyl)benzoic acidHCID 2775585—
Reactant(4,4-Difluoro-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexyl)methanamineHCID 86716274—
ProductN-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-2-methyl-5-trifluoromethyl-benzamideHCID 86716289—

Reaction Steps

From 5-trifluoromethyl-2-methylbenzoic acid and C-[4,4-difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=481.1, tR (minutes, Method D)=0.86

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-2bbf6625f0e44c28a1ab78eca2a3a6ca
Source noteuspto-grants-2015_08