2-Chlorobenzoic Acid → HCID 86716318, compound

HRID 512272Notes

Reaction equation

HRID 512272 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][CH2:12][C:13]1([C:21]2[CH:22]=[CH:23][C:24]([C:27]([OH:30])([CH3:29])[CH3:28])=[N:25][CH:26]=2)[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15][CH2:14]1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][CH2:12][C:13]1([C:21]2[CH:26]=[N:25][C:24]([C:27]([OH:30])([CH3:28])[CH3:29])=[CH:23][CH:22]=2)[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15][CH2:14]1)=[O:6]

Participants

3

Reactant 2

HCID 83742-Chlorobenzoic AcidHCID 86716317HCID 86716317, compound

Product 1

HCID 86716318HCID 86716318, compound

Procedure

From 2-chlorobenzoic acid and 2-[5-(1-aminomethyl-4,4-difluoro-cyclohexyl)-pyridin-2-yl]-propan-2-ol. LCMS (MH+): m/z=423.2, tR (minutes, Method F)=1.78

Sources & evidence

ORD record
ord-1f02279ad2634561a79f13c83b004e97
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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