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HRID51229

反应详情

EQUATION

反应方程式

HRID 51229 的结构方程式

REACTANTS

反应物

2
结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CNC(=O)c1sc(C)c(C)c1C(=O)c1ccccc1
HCID11043951

未命名化合物

PRODUCTS

生成物

1
结构：Cc1sc(C(=O)O)c(C(=O)c2ccccc2)c1C
HCID11821344

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.O
溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

A solution of 16a (0.281 g, 1.03 mmole) in methanol-water 1:1 containing 10% KOH was heated at reflux for 12 hours, neutralized and extracted with ethyl acetate. The solid after evaporation was crystallized from ethanol. Yield 0.19 g, 71%.

WORKUP

后处理

  1. temperatureat reflux for 12 hours
  2. extractionextracted with ethyl acetate
  3. customThe solid after evaporation
  4. customwas crystallized from ethanol