HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 3-Benzoyl-4,5-dimethylthiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Benzoyl-4,5-dimethylthiophene-2-carboxylic acid methylamide | HCID 11043951 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 3-Benzoyl-4,5-dimethylthiophene-2-carboxylic acid | HCID 11821344 | — |
Reaction Steps
A solution of 16a (0.281 g, 1.03 mmole) in methanol-water 1:1 containing 10% KOH was heated at reflux for 12 hours, neutralized and extracted with ethyl acetate. The solid after evaporation was crystallized from ethanol. Yield 0.19 g, 71%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713638B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-e4500b562298474d8b083b3d1e1b340c |
| Source note | uspto-grants-2004_03 |