2-Chlorobenzoic Acid → HCID 86716418, compound

HRID 512364Notes

Reaction equation

HRID 512364 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:11]1([CH2:14][CH:15]([N:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[N:20][CH2:19]2)[CH2:16][NH2:17])[CH2:13][CH2:12]1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:17][CH2:16][CH:15]([N:18]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[N:20][CH2:19]1)[CH2:14][CH:11]1[CH2:13][CH2:12]1)=[O:6]

Participants

3

Reactant 2

HCID 83742-Chlorobenzoic AcidHCID 86716417HCID 86716417, compound

Product 1

HCID 86716418HCID 86716418, compound

Procedure

From 2-chlorobenzoic acid and 3-cyclopropyl-2-(6-(trifluoromethyl)pyrimidin-3-yl)propan-1-amine. LCMS (MH+): m/z=384.1, tR (minutes, Method D)=0.76

Sources & evidence

ORD record
ord-03c589fe1e714be3972563e6a7dc1fd1
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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