2-Chlorobenzoic Acid → 2-Chloro-N-(2-isopropoxy-2-(2-methylpyrimidin-5-yl)ethyl)benzamide

HRID 512376Notes

Reaction equation

HRID 512376 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:11]([O:14][CH:15]([C:18]1[CH:19]=[N:20][C:21]([CH3:24])=[N:22][CH:23]=1)[CH2:16][NH2:17])([CH3:13])[CH3:12]>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:17][CH2:16][CH:15]([O:14][CH:11]([CH3:13])[CH3:12])[C:18]1[CH:19]=[N:20][C:21]([CH3:24])=[N:22][CH:23]=1)=[O:6]

Participants

3

Reactant 2

HCID 83742-Chlorobenzoic AcidHCID 867162282-Isopropoxy-2-(2-methylpyrimidin-5-yl)ethanamine

Product 1

HCID 867164322-Chloro-N-(2-isopropoxy-2-(2-methylpyrimidin-5-yl)ethyl)benzamide

Procedure

From 2-chlorobenzoic acid and 2-isopropoxy-2-(2-methylpyrimidin-5-yl)ethanamine. LCMS (MH+): m/z=334.0, tR (minutes, Method E)=0.52

Sources & evidence

ORD record
ord-5948d598d4c34e818687e71b8ebfcf72
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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