2-Chloro-3-methoxybenzoic acid → 2-Chloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)-3-methoxybenzamide

HRID 512385Notes

Reaction equation

HRID 512385 reaction equation
[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:13][CH:14]([F:31])[C:15]1[N:20]=[CH:19][C:18]([C:21]2([CH2:29][NH2:30])[CH2:26][CH2:25][C:24]([F:28])([F:27])[CH2:23][CH2:22]2)=[CH:17][N:16]=1>>[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:30][CH2:29][C:21]1([C:18]2[CH:17]=[N:16][C:15]([CH:14]([F:31])[F:13])=[N:20][CH:19]=2)[CH2:26][CH2:25][C:24]([F:27])([F:28])[CH2:23][CH2:22]1)=[O:6]

Participants

3

Reactant 2

HCID 162180632-Chloro-3-methoxybenzoic acidHCID 86716443(1-(2-(Difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamine

Product 1

HCID 867164422-Chloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)-3-methoxybenzamide

Procedure

From 2-chloro-3-methoxybenzoic acid and (1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamine. LCMS (MH+): m/z=446.1, tR (minutes, Method F)=2.82

Sources & evidence

ORD record
ord-edaf6d9678bd4666ac1162e7f32da56e
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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