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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512385Generated: October 30, 2026

2-Chloro-3-methoxybenzoic acid → 2-Chloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)-3-methoxybenzamide

https://huagongshe.com/reaction/512385

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-3-methoxybenzoic acidHCID 16218063—
Reactant(1-(2-(Difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamineHCID 86716443—
Product2-Chloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)-3-methoxybenzamideHCID 86716442—

Reaction Steps

From 2-chloro-3-methoxybenzoic acid and (1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamine. LCMS (MH+): m/z=446.1, tR (minutes, Method F)=2.82

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-edaf6d9678bd4666ac1162e7f32da56e
Source noteuspto-grants-2015_08