2-Chloro-3-methoxybenzoic acid → 2-chloro-N-[3-cyclopropyl-2-[6-(trifluoromethyl)-3-pyridyl]propyl]-3-methoxybenzamide

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Reaction Steps

The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-3-methoxybenzoic acid and 3-cyclopropyl-2-(6-trifluoromethyl-pyridin-3-yl)-propylamine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=413.1, tR (minutes, Method G)=2.84. [α]D20=+20.9 (c=0.86 mg/mL,CHCl3)

Provenance & Evidence