HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-methoxybenzoic acid → 2-chloro-3-methoxy-N-(3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-methoxybenzoic acid | HCID 16218063 | — |
| Reactant | 3-Cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propan-1-amine | HCID 86716400 | — |
| Product | 2-chloro-3-methoxy-N-(3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propyl)benzamide | HCID 86716403 | — |
Reaction Steps
The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-3-methoxybenzoic acid and 3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propan-1-amine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=395.1, tR (minutes, Method F)=2.96. [α]D20=+28.21 (c=2.80 mg/mL,CHCl3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102591B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-0b35b725563d47e7b8048457475dd509 |
| Source note | uspto-grants-2015_08 |