反应详情

A mixture of potassium ethyl xanthate (16.0 g, 0.1 mol) and 2-amino-4-methylphenol (12.3 g, 0.1 mol) was dissolved in absolute ethanol (150 mL). The mixture was stirred at reflux overnight. After cooling, the reaction solvent was evaporated under reduced pressure. The resultant residue was dissolved in water (200 mL) and treated with HOAc to pH to 5. The resultant solid was filtered and dried to afford 5-methyl-2-mercaptobenzoxazole (16.0 g, 96% yield).

1. temperatureat reflux overnight
2. temperatureAfter cooling
3. customthe reaction solvent was evaporated under reduced pressure
4. dissolutionThe resultant residue was dissolved in water (200 mL)
5. additiontreated with HOAc
6. filtrationThe resultant solid was filtered
7. customdried