Sulfuric Acid → HCID 22113416, compound

HRID 512453Notes

Reaction equation

HRID 512453 reaction equation
[Cl:1][C:2]([F:14])([F:13])[C:3]1[NH:8][C:7](=[O:9])[C:6]([C:10](N)=[O:11])=[CH:5][CH:4]=1.S(=O)(=O)(O)[OH:16]>>[Cl:1][C:2]([F:14])([F:13])[C:3]1[NH:8][C:7](=[O:9])[C:6]([C:10]([OH:16])=[O:11])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 22113414HCID 22113414, compound

Product 1

HCID 22113416HCID 22113416, compound

Procedure

11.0 g (49.4 mmol) of 6-[chloro(difluoro)methyl]-2-oxo-1,2-dihydropyridine-3-carboxamide were heated in 77 ml of 50% strength sulfuric acid. The mixture was then added to ice water, and the precipitate was filtered off with suction and dried. This gave 7.2 g (65% of theory) of a yellowish powder.

Workup

  1. filtrationthe precipitate was filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-f78862d54f8345d0b9488d62062b1807
Source dataset
uspto-grants-2015_08
Patent number
US09102623B2

Reaction notes

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