Hydrochloric Acid → HCID 59828243, compound

HRID 512473Notes

Reaction equation

HRID 512473 reaction equation
[Cl:1][C:2]([F:16])([F:15])[C:3]1[NH:8][C:7](=[O:9])[C:6]([C:10]([O:12]C)=O)=[CH:5][C:4]=1[I:14].[CH3:17][CH2:18][CH:19]([NH2:22])[CH2:20][CH3:21].Cl>C(#N)C>[Cl:1][C:2]([F:16])([F:15])[C:3]1[NH:8][C:7](=[O:9])[C:6]([C:10]([NH:22][CH:19]([CH2:20][CH3:21])[CH2:18][CH3:17])=[O:12])=[CH:5][C:4]=1[I:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 120193-PentanamineHCID 69233638HCID 69233638, compound

Product 1

HCID 59828243HCID 59828243, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

At room temperature, 400 mg (1.1 mmol) of methyl 6-[chloro(difluoro)methyl]-5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate were dissolved in 5 ml of acetonitrile and stirred with 0.5 ml of 3-pentylamine for 12 h. The reaction mixture was then added to 1N of hydrochloric acid, and the resulting precipitate was filtered off with suction and washed with water. Drying gave 370 mg (72% of theory) of the product.

Workup

  1. filtrationthe resulting precipitate was filtered off with suction
  2. washwashed with water
  3. customDrying
  4. customgave 370 mg (72% of theory) of the product

Sources & evidence

ORD record
ord-b8af0f01f4dc4175b1fb46d6c1c4a11a
Source dataset
uspto-grants-2015_08
Patent number
US09102623B2

Reaction notes

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