Hydrochloric Acid → HCID 59828235, compound

HRID 512478Notes

Reaction equation

HRID 512478 reaction equation
[Cl:1][C:2]([F:18])([F:17])[C:3]([C:6]1[NH:11][C:10](=[O:12])[C:9]([C:13]([O:15]C)=O)=[CH:8][CH:7]=1)([F:5])[F:4].Cl.[CH2:20]([NH2:22])[CH3:21]>>[Cl:1][C:2]([F:18])([F:17])[C:3]([C:6]1[NH:11][C:10](=[O:12])[C:9]([C:13]([NH:22][CH2:20][CH3:21])=[O:15])=[CH:8][CH:7]=1)([F:4])[F:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6341EthylamineHCID 86624094HCID 86624094, compound

Product 1

HCID 59828235HCID 59828235, compound

Procedure

At room temperature, 300 mg (1.04 mmol) of methyl 6-(2-chloro-1,1,2,2-tetrafluoroethyl)-2-oxo-1,2-dihydropyridine-3-carboxylate were stirred in 5 ml of aqueous ethylamine solution (70%) for 14 h. The pH was then adjusted to 2 by addition of 1N hydrochloric acid, and the mixture was extracted with dichloromethane. Drying and concentration of the extract gave 310 mg (98% of theory) of the product.

Workup

  1. extractionthe mixture was extracted with dichloromethane
  2. customDrying
  3. customconcentration of the extract gave 310 mg (98% of theory) of the product

Sources & evidence

ORD record
ord-11f7a37998604ca58a9957f0d049324e
Source dataset
uspto-grants-2015_08
Patent number
US09102623B2

Reaction notes

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