HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-(4-Cyano-benzyl)-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid cyanomethyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 6-Methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711532 | — |
| Reactant | 6-(1-Bromoethyl)pyridine-3-carbonitrile | HCID 86711546 | — |
| Product | 1-(4-Cyano-benzyl)-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid cyanomethyl-amide | HCID 86711574 | — |
Reaction Steps
Examples 47.1-47.20 are prepared in two steps: (1) Amide coupling as described for preparation 9.13 (Procedure A), substituting preparation 4 with preparation 5b and substituting aminoacetonitrile with the appropriate amines, respectively; (2) Alkylation as described for example 2.1, substituting benzyl bromide with preparation 15c, substituting preparation 5 with the intermediates from step 1, and substituting DMF with NMP.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102624B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5fcb79e9ceaa4191824118acd9503434 |
| Source note | uspto-grants-2015_08 |