反应详情

Examples 47.1-47.20 are prepared in two steps: (1) Amide coupling as described for preparation 9.13 (Procedure A), substituting preparation 4 with preparation 5b and substituting aminoacetonitrile with the appropriate amines, respectively; (2) Alkylation as described for example 2.1, substituting benzyl bromide with preparation 15c, substituting preparation 5 with the intermediates from step 1, and substituting DMF with NMP.

1. customExamples 47.1-47.20 are prepared in two steps
2. custompreparation 4