Ethanolamine → HCID 72550410, compound

HRID 512531Notes

Reaction equation

HRID 512531 reaction equation
F[C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[S:13][C:12]([NH:14][C:15]3[CH:24]=[CH:23][C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=3)=[N:11][C:10]=2[C:25]([NH2:27])=[O:26])=[O:7])=[CH:4][CH:3]=1.[NH2:30][CH2:31][CH2:32][OH:33]>CN1C(=O)CCC1.O>[OH:33][CH2:32][CH2:31][NH:30][C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[S:13][C:12]([NH:14][C:15]3[CH:24]=[CH:23][C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=3)=[N:11][C:10]=2[C:25]([NH2:27])=[O:26])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 700EthanolamineHCID 86703372HCID 86703372, compound

Product 1

HCID 72550410HCID 72550410, compoundYield 31.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of 5-(4-fluorobenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide (0.10 g, 0.25 mmol) and 2-aminoethanol (0.15 g, 2.46 mmol) in NMP (1 mL) was treated using a microwave synthesizer for 1 hr (CEM Corp., 180° C.). The, reaction mixture was diluted with water (3 mL), and the resulting solids were collected by filtration. The solids were washed with water, and dried to give 0.035 g (31% yield) of the titled compound.

Workup

  1. customfor 1 hr
  2. custom(CEM Corp., 180° C.)
  3. customThe, reaction mixture
  4. filtrationthe resulting solids were collected by filtration
  5. washThe solids were washed with water
  6. customdried

Sources & evidence

ORD record
ord-5c87a968f5144394b83fe11551f473ce
Source dataset
uspto-grants-2015_08
Patent number
US09102637B2

Reaction notes

Loading…