3-Thenoyl chloride → HCID 86703385、化合物

HRID 512551ノート

反応式

HRID 512551 の反応式
[NH2:1][C:2]1[S:6][C:5]([NH:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=2)=[N:4][C:3]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19].[S:23]1[CH:27]=[CH:26][C:25]([C:28](Cl)=[O:29])=[CH:24]1>N1C=CC=CC=1>[CH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:16]=[CH:17][C:8]=1[NH:7][C:5]1[S:6][C:2]([NH:1][C:28]([C:25]2[CH:26]=[CH:27][S:23][CH:24]=2)=[O:29])=[C:3]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:4]=1

参加物

4

反応物 2

HCID 27763773-Thenoyl chlorideHCID 86703384Ethyl 5-amino-2-(naphthalen-2-ylamino)thiazole-4-carboxylate

生成物 1

HCID 86703385HCID 86703385、化合物収率 40.6%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of ethyl 5-amino-2-(naphthalen-2-ylamino)thiazole-4-carboxylate (100 mg, 0.32 mmol) in pyridine (3 mL) was added 3-thiophene carbonyl chloride (61 mg, 0.42 mmol) at 0° C. The mixture was allowed to warm to rt and stirred overnight. The reaction was quenched with ice-water, and the mixture was extracted with EtOAc. The organic layer was washed with water, and dried over Na2SO4. The solvent was evaporated, and the resulting solids were collected and washed with EtOAc to give 55 mg (40% yield) of the titled compound.

後処理

  1. customThe reaction was quenched with ice-water
  2. extractionthe mixture was extracted with EtOAc
  3. washThe organic layer was washed with water
  4. dry with materialdried over Na2SO4
  5. customThe solvent was evaporated
  6. customthe resulting solids were collected
  7. washwashed with EtOAc

出典と根拠

ORDレコード
ord-2c3a60cb9e45420b909f5fb98183a4a6
出典データセット
uspto-grants-2015_08
特許番号
US09102637B2

反応ノート

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