反应详情

To a solution of ethyl 5-amino-2-(naphthalen-2-ylamino)thiazole-4-carboxylate (100 mg, 0.32 mmol) in pyridine (3 mL) was added 3-thiophene carbonyl chloride (61 mg, 0.42 mmol) at 0° C. The mixture was allowed to warm to rt and stirred overnight. The reaction was quenched with ice-water, and the mixture was extracted with EtOAc. The organic layer was washed with water, and dried over Na2SO4. The solvent was evaporated, and the resulting solids were collected and washed with EtOAc to give 55 mg (40% yield) of the titled compound.

1. customThe reaction was quenched with ice-water
2. extractionthe mixture was extracted with EtOAc
3. washThe organic layer was washed with water
4. dry with materialdried over Na2SO4
5. customThe solvent was evaporated
6. customthe resulting solids were collected
7. washwashed with EtOAc