HCID 66677188, compound → HCID 66677844, compound

HRID 512583Notes

Reaction equation

HRID 512583 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([CH:16]2[C:21](=[O:22])[CH2:20][CH2:19][CH2:18][C:17]2=[O:23])=[C:11]([CH3:24])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.CO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH3:24])[C:12]([CH:16]2[C:21](=[O:22])[CH2:20][CH2:19][CH2:18][C:17]2=[O:23])=[C:13]([CH3:15])[CH:14]=1

Participants

6

Reactant 2

HCID 66677188HCID 66677188, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66677844HCID 66677844, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 2-(4-benzyloxy-2,6-dimethylphenyl)cyclohexane-1,3-dione (0.57 g, 0.0018 mol) in ethyl acetate (30 ml) and methanol (530 ml) is added 5% palladium on carbon (0.100 g), and the suspension is then stirred under 4 bar hydrogen pressure for 5 hours. The suspension is filtered through diatomaceous earth and the filtrate evaporated under reduced pressure to afford 2-(4-hydroxy-2,6-dimethylphenyl)cyclohexane-1,3-dione as a grey solid.

Workup

  1. filtrationThe suspension is filtered through diatomaceous earth
  2. customthe filtrate evaporated under reduced pressure

Sources & evidence

ORD record
ord-c5c58da8cd5c4c4783cb6e1870b3a70e
Source dataset
uspto-grants-2015_08
Patent number
US09102642B2

Reaction notes

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