Phosphorus oxychloride → HCID 15228889, compound

HRID 5128Notes

Reaction equation

HRID 5128 reaction equation
[CH:1]1[CH:6]=[C:5]2[C:7]([C:15]([OH:17])=[O:16])=[C:8]([C:12]([OH:14])=O)[C:9]([NH:11][C:4]2=[CH:3][CH:2]=1)=[O:10].P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[C:15]1(=[O:16])[C:7]2[C:5]3[CH:6]=[CH:1][CH:2]=[CH:3][C:4]=3[NH:11][C:9](=[O:10])[C:8]=2[C:12](=[O:14])[O:17]1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 8045962-Oxo-1,2-dihydroquinoline-3,4-dicarboxylic acid

Product 1

HCID 15228889HCID 15228889, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 2(1H)-Oxo-quinoline-3,4-dicarboxylic acid (2 g), phosphorous oxychloride (4 g) and dry chloroform (30 mL) was heated at reflux for 2 h. The solvent and excess reagents are removed in vacuo and the residue was treated with ice water to afford Furo[3,4-c]quinoline-1,3,4(5H)-trione as a yellow solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 h
  3. customThe solvent and excess reagents are removed in vacuo
  4. additionthe residue was treated with ice water

Sources & evidence

ORD record
ord-146b31ec172a43eb9907724661a2a7f5
Source dataset
uspto-grants-1993_09
Patent number
US05243049

Reaction notes

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