反应详情

温度

30 °C

To a pre-cooled solution of racemic methyl lactate (200 g) in dimethyl formamide (400 ml) at 0-10° C., added benzyl chloride (218.8 g). Sodium tertiary butoxide (224.6 g) was added to the reaction mixture at 0-10° C. and stirred for 6 hours at 25-35° C. After completion of the reaction, the reaction mixture was quenched with water and extracted with toluene. The toluene layer was washed with water followed by 10% sodium chloride solution. The obtained toluene layer containing title compound was taken to next step.

1. customAfter completion of the reaction
2. customthe reaction mixture was quenched with water
3. extractionextracted with toluene
4. washThe toluene layer was washed with water
5. additionThe obtained toluene layer containing title compound