6-(Trifluoromethyl)indoline → 1-(1-(6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)-6-(trifluoromethyl)indoline

HRID 512836Notes

Reaction equation

HRID 512836 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][NH:9]2)=[CH:5][CH:4]=1.[CH3:14][N:15]1[CH:19]=[C:18]([C:20]2[N:25]=[N:24][C:23]([N:26]3[CH2:31][CH2:30][C:29](=O)[CH2:28][CH2:27]3)=[CH:22][CH:21]=2)[CH:17]=[N:16]1>>[CH3:14][N:15]1[CH:19]=[C:18]([C:20]2[N:25]=[N:24][C:23]([N:26]3[CH2:31][CH2:30][CH:29]([N:9]4[C:10]5[C:6](=[CH:5][CH:4]=[C:3]([C:2]([F:1])([F:12])[F:13])[CH:11]=5)[CH2:7][CH2:8]4)[CH2:28][CH2:27]3)=[CH:22][CH:21]=2)[CH:17]=[N:16]1

Participants

3

Reactant 2

HCID 101764376-(Trifluoromethyl)indolineHCID 896139951-(6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-one

Product 1

HCID 763147211-(1-(6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)-6-(trifluoromethyl)indoline

Procedure

The title compound was prepared following the procedure as described in Example 5, STEP 4, reacting 6-trifluoromethylindoline and 1-(6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-one.

Sources & evidence

ORD record
ord-778f5a1f3b6c4ba09124dadb61d128ea
Source dataset
uspto-grants-2015_08
Patent number
US09102669B2

Reaction notes

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