1-Propyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 6-fluoro-1-(1-(6-(1-propyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)indoline

HRID 512844Notes

Reaction equation

HRID 512844 reaction equation
[CH2:1]([N:4]1[CH:8]=[C:7](B2OC(C)(C)C(C)(C)O2)[CH:6]=[N:5]1)[CH2:2][CH3:3].Cl[C:19]1[N:24]=[N:23][C:22]([N:25]2[CH2:30][CH2:29][CH:28]([N:31]3[C:39]4[C:34](=[CH:35][CH:36]=[C:37]([F:40])[CH:38]=4)[CH2:33][CH2:32]3)[CH2:27][CH2:26]2)=[CH:21][CH:20]=1>>[F:40][C:37]1[CH:38]=[C:39]2[C:34]([CH2:33][CH2:32][N:31]2[CH:28]2[CH2:29][CH2:30][N:25]([C:22]3[N:23]=[N:24][C:19]([C:7]4[CH:6]=[N:5][N:4]([CH2:1][CH2:2][CH3:3])[CH:8]=4)=[CH:20][CH:21]=3)[CH2:26][CH2:27]2)=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 27604871-Propyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 896144661-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline

Product 1

HCID 763328416-fluoro-1-(1-(6-(1-propyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)indoline

Procedure

The title compound was prepared following the procedure as described in Example 1, Method A, reacting 1-propylpyrazole-4-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Sources & evidence

ORD record
ord-5e51d39dd6ad437eaf438bb80ffed194
Source dataset
uspto-grants-2015_08
Patent number
US09102669B2

Reaction notes

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