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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512844Generated: October 30, 2026

1-Propyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 6-fluoro-1-(1-(6-(1-propyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)indoline

https://huagongshe.com/reaction/512844

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Propyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 2760487—
Reactant1-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindolineHCID 89614466—
Product6-fluoro-1-(1-(6-(1-propyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)indolineHCID 76332841—

Reaction Steps

The title compound was prepared following the procedure as described in Example 1, Method A, reacting 1-propylpyrazole-4-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102669B2
Source datasetuspto-grants-2015_08
ORD IDord-5e51d39dd6ad437eaf438bb80ffed194
Source noteuspto-grants-2015_08