1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester → Ethyl 2-(4-(6-(4-(6-fluoroindolin-1-yl)piperidin-1-yl)pyridazin-3-yl)-1H-pyrazol-1-yl)acetate

HRID 512845Notes

Reaction equation

HRID 512845 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][N:7]1[CH:11]=[C:10](B2OC(C)(C)C(C)(C)O2)[CH:9]=[N:8]1)=[O:5])[CH3:2].Cl[C:22]1[N:27]=[N:26][C:25]([N:28]2[CH2:33][CH2:32][CH:31]([N:34]3[C:42]4[C:37](=[CH:38][CH:39]=[C:40]([F:43])[CH:41]=4)[CH2:36][CH2:35]3)[CH2:30][CH2:29]2)=[CH:24][CH:23]=1>>[F:43][C:40]1[CH:41]=[C:42]2[C:37]([CH2:36][CH2:35][N:34]2[CH:31]2[CH2:32][CH2:33][N:28]([C:25]3[N:26]=[N:27][C:22]([C:10]4[CH:9]=[N:8][N:7]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:11]=4)=[CH:23][CH:24]=3)[CH2:29][CH2:30]2)=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 162183851-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol esterHCID 896144661-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline

Product 1

HCID 89614506Ethyl 2-(4-(6-(4-(6-fluoroindolin-1-yl)piperidin-1-yl)pyridazin-3-yl)-1H-pyrazol-1-yl)acetate

Procedure

Ethyl 2-(4-(6-(4-(6-fluoroindolin-1-yl)piperidin-1-yl)pyridazin-3-yl)-1H-pyrazol-1-yl)acetate was prepared according to the procedure as described in Example 1, Method A, STEP 4, reacting 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Sources & evidence

ORD record
ord-15693dafde464711b5931ed762719162
Source dataset
uspto-grants-2015_08
Patent number
US09102669B2

Reaction notes

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