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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512845Generated: October 30, 2026

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester → Ethyl 2-(4-(6-(4-(6-fluoroindolin-1-yl)piperidin-1-yl)pyridazin-3-yl)-1H-pyrazol-1-yl)acetate

https://huagongshe.com/reaction/512845

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol esterHCID 16218385—
Reactant1-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindolineHCID 89614466—
ProductEthyl 2-(4-(6-(4-(6-fluoroindolin-1-yl)piperidin-1-yl)pyridazin-3-yl)-1H-pyrazol-1-yl)acetateHCID 89614506—

Reaction Steps

Ethyl 2-(4-(6-(4-(6-fluoroindolin-1-yl)piperidin-1-yl)pyridazin-3-yl)-1H-pyrazol-1-yl)acetate was prepared according to the procedure as described in Example 1, Method A, STEP 4, reacting 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102669B2
Source datasetuspto-grants-2015_08
ORD IDord-15693dafde464711b5931ed762719162
Source noteuspto-grants-2015_08